Sunday, 18 January 2015 13:52

Hepatotoxic effects of aflatoxin in workers exposed to wheat flour dust

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Mohgah Sh. Abdalla1, Amal Saad-Hussein2, Wafaa Gh. Shousha1, Gehan Moubarz2,3 and Aya H. Mohamed1

1Department of Chemistry, Faculty of Science, Helwan University, Egypt, 2Department of Environmental & Occupational Medicine, National Research Centre, and 3Department ofChemistry, Faculty of Science and Arts-Khulais, King Abdulaziz University, Saudi Arabia


Aflatoxins are a group of mycotoxins produced by Aspergillus flavus and Aspergillus parasiticus . They are potent inducers of hepatotoxicity. Those toxic compounds are ubiquitously found in food commodities such as nuts, cereals, spices and milks and dairy products. Aflatoxin B1 (AFB1) has been classified by the International Agency for Research on Cancer (IARC) as Group 1 carcinogen. Once AFB1 is ingested by humans, it is metabolized by liver enzymes into many metabolites. The study aimed to estimate the hepatotoxicity of AFB1 in workers occupationally exposed to wheat flour dust. Statistical analysis of the results revealed that Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), γ-glutamyl transpeptidase (GGT), Alkaline phosphates (ALP)  levels in the exposed workers were significantly higher compared to their controls. In the exposed workers, there were significant correlations between AFB1/Alb and the duration of exposure, and between the levels of AST and ALT and the level of AFB1/Alb. The present study that the serum AFB1/Alb was significantly correlated with the duration of exposure in workers exposed to wheat flour dust, and such elevation in AFB1/Alb levels  have hepatotoxic effects in the exposed  workers.

Keywords; Aflatoxin; Aspartate aminotransferase; Alanine aminotransferase; γ-glutamyl transpeptidase; Alkaline phosphates.

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