Wagih Abd ElFattah El-Shouny
Antimicrobial activity of chamomile acetone extract against some experimentally-induced skin infections in mice
Wagih Abd ElFattah El-Shouny1, Eman H.F. Abd El-Zaher1*, Maha Abd El-Fattah Khalil1,2, Olaa Abd El-Salam1
1Botany Department, Faculty of Science, Tanta University, Tanta, Egypt
2Present address of M.A. Khalil: Biology Department, Faculty of Science, Taif University, Taif, KSA
Abstract: The aim of the study was to find out the antimicrobial activity of chamomile flower acetone extract on mice skin infection and to compare the results with some traditional medicaments. Methods: A total of 2 isolates (1bacterial & 1fungi) isolated from skin lesions of infected patients. Acetonic flower extract of chamomile was investigated for their antimicrobial activity against bacterial strains, one Gram positive (Staphylococcus aureus), and one fungal strains (Candida albicans1). In this study the antibacterial activity of chamomile acetonic extracts showed highest inhibition zone (27mm) against tested bacteria isolates Staphylococcus aureus also it gave the high antifungal activity (18mm) against Candida albicas1 at concentrations 400μg/ml. Gas chromatography-mass spectrometry (GC-MS) analysis of chamomile acetone flowers extracts were detected. Vivo trials were performed on mice to determine the effectiveness of herbal plant extracts on skin. Conclusions: The study revealed that the chamomile flowers acetone extract has a higher antimicrobial activity against Staphylococcus aureus and Candida albicans1 than the traditional drugs on experimentally-induced skin infection in mice. The study recommends further studies on other micro-organisms and on human beings.
Key words: Chamomile, Antimicrobial, Skin infections, GC-MS, Topical cream